Water → HCID 178518718, compound

HRID 1883554Notes

Reaction equation

HRID 1883554 reaction equation
Br[C:2]1[NH:3][C:4](=[O:11])[C:5]2[NH:6][CH:7]=[N:8][C:9]=2[N:10]=1.[N:12]1([CH2:18][CH2:19][NH2:20])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1.O>COCCO>[N:12]1([CH2:18][CH2:19][NH:20][C:2]2[NH:3][C:4](=[O:11])[C:5]3[N:6]=[CH:7][NH:8][C:9]=3[N:10]=2)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

5

Reactant 3

HCID 962WaterHCID 33944N-(2-Aminoethyl)piperidineHCID 1354139912-Bromohypoxanthine

Product 1

HCID 178518718HCID 178518718, compoundYield 76.2%

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

A mixture of 2-bromohypoxanthine (6 g, 28 mmol) and 2-piperidinoethylamine (7 ml, 56 mmol) in 2-methoxyethanol (30 ml) was heated to reflux overnight. The mixture was cooled to ambient temperature, giving rise to a yellow precipitate. Additional precipitate was generated on addition of water (50 ml). After stirring for 1 hour, the suspension was filtered and the solid obtained was washed with water and dried under vacuum to give the title compound (5.6 g). LC/MS SYSTEM C Rt=0.82 mins, m/z=263 MH+.

Workup

  1. temperaturewas heated
  2. temperatureto reflux overnight
  3. customgiving rise to a yellow precipitate
  4. filtrationthe suspension was filtered
  5. customthe solid obtained
  6. washwas washed with water
  7. customdried under vacuum

Sources & evidence

ORD record
ord-71eaa2b0b20a461ba04120e9b85faa70
Source dataset
uspto-grants-2004_07
Patent number
US06762170B1

Reaction notes

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