Trifluoroacetic acid → HCID 86759491, compound

HRID 1883652Notes

Reaction equation

HRID 1883652 reaction equation
C([C:5]1[C:13]([CH2:14][N:15]([C:17](=[O:24])[CH:18](O)CC(C)C)C)=[C:12]([NH2:25])[CH:11]=[CH:10][C:6]=1[C:7]([OH:9])=[O:8])(C)(C)C.[C:26]([OH:32])([C:28]([F:31])([F:30])[F:29])=[O:27]>C(Cl)Cl>[F:29][C:28]([F:31])([F:30])[C:26]([OH:32])=[O:27].[NH2:25][C:12]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:13]=1[CH2:14][N:15]([O:27][CH2:26][CH3:28])[C:17]([CH3:18])=[O:24]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23508332HCID 23508332, compound

Product 1

HCID 86759491HCID 86759491, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of t-butyl-4-amino-3-[(2-hydroxy-4,N-dimethylpentanoylamino)methyl]benzoic acid (2.98 g, 9.67 mmole) in CH2Cl2 (20 mL) at RT was added TFA (20 mL). After 12 hr, the reaction contents were concentrated, washed with hexanes and dried under high vacuum overnight affording the title compound as an orange oil (3.51 g, 9.60 mmol). This product was used without further purification: MS (ES) m/e 253 (M+H-TFA)+.

Workup

  1. customthe reaction contents
  2. concentrationwere concentrated
  3. washwashed with hexanes
  4. customdried under high vacuum overnight

Sources & evidence

ORD record
ord-a96a67a1562349efa9ce863012343fe6
Source dataset
uspto-grants-2004_07
Patent number
US06762201B1

Reaction notes

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