HCID 23508536, compound → HCID 23508516, compound

HRID 1883702Notes

Reaction equation

HRID 1883702 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:5][CH:4]=1>ClCCCl>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:7][CH:8]=1

Participants

3

Reactant 1

HCID 23508536HCID 23508536, compound

Product 1

HCID 23508516HCID 23508516, compoundYield 90.1%

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The procedure of Preparation Example 2 was repeated, except that 208 mg of N-(4′-methoxybiphenyl-2-yl)methanesulfonamide was used in place of 4′-methoxy-2-biphenylacetonitrile, and 1,2-dichloroethane was used in place of methylene chloride. The resulting crude product was purified by TLC (using a 2:1 mixture of hexane and ethyl acetate as the developing solvent) to obtain 178 mg of N-(4′-hydroxy-biphenyl-2-yl)methanesulfonamide.

Workup

  1. customThe procedure of Preparation Example 2
  2. customThe resulting crude product was purified by TLC (
  3. additiona 2:1 mixture of hexane and ethyl acetate as the developing solvent)

Sources & evidence

ORD record
ord-2fa2ae24f6ee4d12bfef705bd5ab26a6
Source dataset
uspto-grants-2004_07
Patent number
US06762205B1

Reaction notes

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