HCID 23508390, compound → HCID 23508377, compound

HRID 1883704Notes

Reaction equation

HRID 1883704 reaction equation
[S:1]([NH:5][C:6]1[CH:11]=[CH:10][C:9](/[C:12](=[CH:15]/[C:16]2[CH:21]=[CH:20][C:19]([O:22]C)=[CH:18][CH:17]=2)/[C:13]#[N:14])=[CH:8][CH:7]=1)(=[O:4])(=[O:3])[NH2:2]>ClCCCl>[S:1]([NH:5][C:6]1[CH:11]=[CH:10][C:9](/[C:12](=[CH:15]/[C:16]2[CH:17]=[CH:18][C:19]([OH:22])=[CH:20][CH:21]=2)/[C:13]#[N:14])=[CH:8][CH:7]=1)(=[O:4])(=[O:3])[NH2:2]

Participants

3

Reactant 1

HCID 23508390HCID 23508390, compound

Product 1

HCID 23508377HCID 23508377, compoundYield 28.2%

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The procedure of Preparation Example 2 was repeated, except that 63 mg of (2Z)-2-[4-(N-sulfamoylamino)phenyl]-3-(4-methoxyphenyl)-prop-2-enenitrile was used in place of 4′-methoxy-2-biphenylacetonitrile, and 1,2-dichloroethane was used in place of methylene chloride. The resulting crude product was purified by TLC (using a 2:1 mixture of chloroform and acetone as the developing solvent) to obtain 17 mg of (2Z)-2-[4-(sulfamoylamino)phenyl]-3-(4-hydroxyphenyl)prop-2-enenitrile.

Workup

  1. customThe procedure of Preparation Example 2
  2. customThe resulting crude product was purified by TLC (
  3. additiona 2:1 mixture of chloroform and acetone as the developing solvent)

Sources & evidence

ORD record
ord-91c7fe748df54c46b5cd1ad70a1c2b31
Source dataset
uspto-grants-2004_07
Patent number
US06762205B1

Reaction notes

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