HRID1883775

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8082

Piperidine

C5H11N

HCID846150

4-(piperidin-1-ylmethyl)aniline

C12H18N2

结构：CCOC(=O)c1ccc2c(c1)N(C(C)=O)C(=O)C2=C(OCC)c1ccccc1

HCID68527561

Ethyl 1-acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylate

C22H21NO5

PRODUCTS

生成物

$结构：CCOC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN2CCCCC2)cc1)c1ccccc1$

HCID178468589

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度: 100 °C

PROCEDURE

实验过程

1.5 g of 1-acetyl-3-(1-ethoxy-1-phenylmethylene)-6-ethoxycarbonyl-2-indolinone and 1.1 g of 4-(piperidin-1-yl-methyl)-aniline are dissolved in 15 ml of dimethylformamide and stirred for 45 minutes at 100° C. After cooling 5.0 ml of piperidine are added and the mixture is stirred for another 3 hours at room temperature. The solvent is removed and the residue purified over an aluminium oxide column (activity: 2-3) with methylene chloride/ethanol (100:3) as eluant.

WORKUP

后处理

additionare added
stirringthe mixture is stirred for another 3 hours at room temperature
customThe solvent is removed
customthe residue purified over an aluminium oxide column (activity: 2-3) with methylene chloride/ethanol (100:3) as eluant

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-96f50ce8105c4798aeb7c5fe5e6a793c
来源数据集: uspto-grants-2004_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06762180B1
来源说明: uspto-grants-2004_07

反应 SMILES

C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:11]=2)[C:6](=[C:18](OCC)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:5]1=[O:28])(=O)C.[N:29]1([CH2:35][C:36]2[CH:42]=[CH:41][C:39]([NH2:40])=[CH:38][CH:37]=2)[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1.N1CCCCC1>CN(C)C=O>[N:29]1([CH2:35][C:36]2[CH:37]=[CH:38][C:39]([NH:40]/[C:18](=[C:6]3\[C:5](=[O:28])[NH:4][C:12]4[C:7]\3=[CH:8][CH:9]=[C:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:11]=4)/[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:41][CH:42]=2)[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]1