Dimethylformamide → HCID 178497166, compound

HRID 1883889Notes

Reaction equation

HRID 1883889 reaction equation
[NH2:1][CH2:2][C:3]1[CH:30]=[CH:29][C:6]([NH:7]/[C:8](=[C:15]2\[C:16](=[O:28])[NH:17][C:18]3[C:23]\2=[CH:22][CH:21]=[C:20]([C:24]([O:26][CH3:27])=[O:25])[CH:19]=3)/[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.C([N:33]([CH2:36]C)CC)C.C[N:39](C)C=O>>[NH:1]([CH2:2][C:3]1[CH:4]=[CH:5][C:6]([NH:7]/[C:8](=[C:15]2\[C:16](=[O:28])[NH:17][C:18]3[C:23]\2=[CH:22][CH:21]=[C:20]([C:24]([O:26][CH3:27])=[O:25])[CH:19]=3)/[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)=[CH:29][CH:30]=1)[C:36]([NH2:33])=[NH:39]

Participants

4

Reactant 3

HCID 6228Dimethylformamide2×HCID 8471TriethylamineHCID 178497157HCID 178497157, compound

Product 1

HCID 178497166HCID 178497166, compound

Procedure

300 mg of 3-Z-[1-(4-aminomethyl-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone are dissolved in 5 ml of dimethylformamide and 300 ml of triethylamine are added. Then 700 mg of 3,5-dimethylpyrazol-1-carboxylic acid amidine in 5 ml of dimethylformamide are added. After one day of stirring at room temperature the reaction solution is concentrated by rotary evaporation. The residue is dried at 100° C. in vacuo.

Workup

  1. concentrationis concentrated by rotary evaporation
  2. customThe residue is dried at 100° C. in vacuo

Sources & evidence

ORD record
ord-1e5b0322fbf24e0a96db780a39581e7f
Source dataset
uspto-grants-2004_07
Patent number
US06762180B1

Reaction notes

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