Acetic Acid → N-(10-amino-9-bromo-1,2-dihydro-1-oxobenzo[f]quinazolin-3-yl)pivalamide

HRID 1883998Notes

Reaction equation

HRID 1883998 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:14]=[CH:13][C:12]3[N:11]=[C:10]([NH:15][C:16](=[O:21])[C:17]([CH3:20])([CH3:19])[CH3:18])[NH:9][C:8](=[O:22])[C:7]=3[C:6]=2[C:23]=1[N+:24]([O-])=O.C(O)(=O)C.C(Cl)(Cl)Cl.C(=O)(O)[O-].[Na+]>C(O)C.[Fe].O>[NH2:24][C:23]1[C:6]2[C:7]3[C:8](=[O:22])[NH:9][C:10]([NH:15][C:16](=[O:21])[C:17]([CH3:19])([CH3:20])[CH3:18])=[N:11][C:12]=3[CH:13]=[CH:14][C:5]=2[CH:4]=[CH:3][C:2]=1[Br:1]

Participants

8

Reactant 4

HCID 176Acetic AcidHCID 6212ChloroformHCID 516892Sodium BicarbonateHCID 135838163N-(9-bromo-1,2-dihydro-10-nitro-1-oxobenzo[f]quinazolin-3-yl)pivalamide

Product 1

HCID 135838115N-(10-amino-9-bromo-1,2-dihydro-1-oxobenzo[f]quinazolin-3-yl)pivalamide

Reagents, catalysts & solvents 3

HCID 23925IronCatalystHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of N-(9-bromo-1,2-dihydro-10-nitro-1-oxobenzo[f]quinazolin-3-yl)pivalamide (0.8 g, 1.9 mmoles) and iron powder (0.44 g, 7.8 mmoles) in ethanol:glacial acetic acid/1:1 (25 ml) was stirred and heated to reflux under a nitrogen atmosphere for 3 hours. The reaction mixture was poured into chloroform:water/2:1 (150 ml) and neutralized by addition of solid sodium bicarbonate. The chloroform layer was separated, and the aqueous phase was washed twice with chloroform (50 ml each). Combined chloroform layers were dried over sodium sulfate, filtered and evaporated under reduced pressure. The crude product was purified on a silica gel column eluting with chloroform to give N-(10-amino-9-bromo-1,2-dihydro-1-oxobenzo[f]quinazolin-3-yl)pivalamide as a bright yellow solid. (0.66 g, 89%) 1H NMR (DMSO-d6, 200 MHz) δ: 1.27 (s, 9H, t-butyl); 6.51 (s, 2H, NH2); 7.22 (d, J=8.4 Hz, 1H, Ar); 7.51 (br d, J=9 Hz, 1H, Ar); 7.72 (d, J=8.4 Hz, 1H, Ar); 8.12 (d, J=9.0 Hz, 1H, Ar); 11.40 (br s, 1H, NH); 12.45 (br s, 1H, NH).

Workup

  1. temperatureheated
  2. temperatureto reflux under a nitrogen atmosphere for 3 hours
  3. customThe chloroform layer was separated
  4. washthe aqueous phase was washed twice with chloroform (50 ml each)
  5. dry with materialCombined chloroform layers were dried over sodium sulfate
  6. filtrationfiltered
  7. customevaporated under reduced pressure
  8. customThe crude product was purified on a silica gel column
  9. washeluting with chloroform

Sources & evidence

ORD record
ord-4652f58bc8494ff0a2b1ef84409338fa
Source dataset
uspto-grants-2004_07
Patent number
US06762188B1

Reaction notes

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