Ammonium Hydroxide → HCID 10087344, compound

HRID 1884142Notes

Reaction equation

HRID 1884142 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)=[CH:10][C:9]=1[F:23])=[O:6].[OH-].[NH4+:26]>C1COCC1>[F:23][C:9]1[CH:10]=[C:11]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[CH:12]=[CH:13][C:8]=1[NH:7][C:5](=[O:6])[CH2:4][C:3]([NH2:26])=[O:2]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 9927687HCID 9927687, compound

Product 1

HCID 10087344HCID 10087344, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of N-[2-fluoro-4-(4-fluoro-benzyloxy)-phenyl]-malonamic acid methyl ester (150 mg, 0.45 mmol) and ammonium hydroxide (2.0 mL) in THF (1.0 ml) in a sealed tube was heated at 55° C. for 6 h. After cooling to room temperature the mixture was evaporated and the title compound (60 mg, 42%) was purified by trituration from diethylether. MS: m/e=321.2 (M++H).

Workup

  1. customwas evaporated
  2. customthe title compound (60 mg, 42%) was purified by trituration from diethylether

Sources & evidence

ORD record
ord-d65d86e379bb4838a4506b59fc6a84a4
Source dataset
uspto-grants-2004_07
Patent number
US06762320B2

Reaction notes

Loading…