Methane → HCID 23707597, compound

HRID 1884397Notes

Reaction equation

HRID 1884397 reaction equation
[OH-].[Na+:2].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([S:16]([CH2:19][CH:20]([CH2:24][S:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:21]([OH:23])=[O:22])(=[O:18])=[O:17])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.C>CO>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:11]=[CH:12][C:13]([S:16]([CH2:19][CH:20]([CH2:24][S:25][C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=3)[C:21]([O-:23])=[O:22])(=[O:17])=[O:18])=[CH:14][CH:15]=2)=[CH:8][CH:9]=1.[Na+:2]

Participants

5

Reactant 3

HCID 297MethaneHCID 14798Sodium HydroxideHCID 9824852HCID 9824852, compound

Product 1

HCID 23707597HCID 23707597, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Sodium hydroxide (1 M, 48 mL) was added to a solution in methanol (75 mL) of 3-[(4′-chloro[1,1′-biphenyl]-4-yl)sulfonyl]-2(RS)-[(phenylsulfanyl)-methyl]propanoic acid (20 g, obtained as described in Example 1). Charcoal was added and the mixture was filtered. Concentration of the filtrate to 1/3 of the original volume furnished a shiny precipitate, which was collected by filtration and sequentially washed with cold water, ethanol and diethyl ether. Drying to a constant weight provided 19 g of the title compound as white crystals.

Workup

  1. filtrationthe mixture was filtered
  2. customConcentration of the filtrate to 1/3 of the original volume furnished a shiny precipitate, which
  3. filtrationwas collected by filtration
  4. washsequentially washed with cold water, ethanol and diethyl ether
  5. customDrying to a constant weight

Sources & evidence

ORD record
ord-8037baceb43b45ef836ae128d8c300af
Source dataset
uspto-grants-2004_07
Patent number
US06765003B1

Reaction notes

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