Hydrochloric Acid → 4-(1-Aminonaphthalen-4-yloxy)-2h-pyran-2-one hydrochloride

HRID 1884613Notes

Reaction equation

HRID 1884613 reaction equation
C(OC(=O)[NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][O:22][C:21](=[O:25])[CH:20]=2)=[CH:10][CH:9]=1)(C)(C)C.[ClH:27]>O1CCOCC1.CCOCC>[ClH:27].[NH2:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][O:22][C:21](=[O:25])[CH:20]=2)=[CH:10][CH:9]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 11439599[4-(2-oxo-2H-pyran-4-yloxy)-naphthalen-1-yl]-carbamic acid tert-butyl ester

Product 1

HCID 235058064-(1-Aminonaphthalen-4-yloxy)-2h-pyran-2-one hydrochloride

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent2×

Procedure

A mixture of [4-(2-oxo-2H-pyran-4-yloxy)-naphthalen-1-yl]-carbamic acid tert-butyl ester (0.287 g) and HCl (2 mL of a 4N solution in dioxane) in 4 mL of dioxane was stirred overnight, diluted with ether and filtered. The filtrate was dried providing 4-(4-amino-naphthalen-1-yloxy)-pyran-2-one hydrochloride salt.

Workup

  1. filtrationfiltered
  2. customThe filtrate was dried

Sources & evidence

ORD record
ord-ae4974a70fd049d8ad985f4467709788
Source dataset
uspto-grants-2004_07
Patent number
US06765009B2

Reaction notes

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