1-Iodopropane → HCID 22112627, compound

HRID 1885110Notes

Reaction equation

HRID 1885110 reaction equation
[C:1]([O:6][CH3:7])(=[O:5])[C@@H:2]([CH3:4])[OH:3].I[CH2:9][CH2:10][CH3:11]>>[CH2:9]([O:3][CH:2]([CH3:4])[C:1]([O:6][CH3:7])=[O:5])[CH2:10][CH3:11]

Participants

3

Reactant 2

HCID 336431-IodopropaneHCID 637514(+)-Methyl lactate

Product 1

HCID 22112627HCID 22112627, compoundYield 71.7%

Procedure

160 g of methyl D-lactate and 524 g of 1-iodopropane were mixed in a four-necked flask, and 471 g of freshly prepared Ag2O was gradually added. Then, the mixture was stirred at 60°-65° C. for 1 hour and subjected to filtration. The filtrated product was washed with ether and the ether was distilled off from the filtrate, which was then distilled in vacuo to obtain 161 g of methyl 2-propoxypropionate.

Workup

  1. addition471 g of freshly prepared Ag2O was gradually added
  2. filtrationsubjected to filtration
  3. washThe filtrated product was washed with ether
  4. distillationthe ether was distilled off from the filtrate, which
  5. distillationwas then distilled in vacuo

Sources & evidence

ORD record
ord-36ced603619e406a978cedbda91daa76
Source dataset
uspto-grants-1992_09
Patent number
US05143643

Reaction notes

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