反应详情

Ethyl 2-butyryl-3-(2-fluorophenylamino)acrylate (37 g, 0.13 mol) was added in portions to boiling diphenyl ether (450 ml), then heated at reflux for 1.5 hours. After partial cooling the mixture was diluted with petroleum ether (50 ml). Filtration and washing with petroleum ether gave 3-butyryl-8-fluoro-4(1H)-quinolone (26.5 g), m.p. 176°-178°.

1. temperatureheated
2. temperatureat reflux for 1.5 hours
3. temperatureAfter partial cooling the mixture
4. filtrationFiltration
5. washwashing with petroleum ether