Iodoethane → HCID 22845729, compound

HRID 1885307Notes

Reaction equation

HRID 1885307 reaction equation
Cl.[CH2:2]([O:4][C:5]([C@@H:7]1[CH2:11][C@H:10]([OH:12])[CH2:9][NH:8]1)=[O:6])[CH3:3].[CH2:13](N(CC)CC)[CH3:14].C(I)C>C(Cl)(Cl)Cl>[CH2:2]([O:4][C:5]([C@@H:7]1[CH2:11][C@H:10]([OH:12])[CH2:9][N:8]1[CH2:13][CH3:14])=[O:6])[CH3:3]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 8471TriethylamineHCID 12709301142347-82-8

Product 1

HCID 22845729HCID 22845729, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a suspension of 12 g of (2S,4S)-2-ethoxycarbonyl-4-hydroxy pyrrolidine hydrochloride obtained in the preceeding para. (1) in 60 ml of chloroform, were added 12.42 g of triethylamine and the combined was added with 17.22 g of ethyl iodide and heat-refluxed for 4 hours. The reaction mixture was after-treated to obtain (2S,4S)2-ethoxycarbonyl-N-ethyl-4-hydroxy pyrrolidine as an oily (product Yield 9.55 g.

Workup

  1. customobtained in the preceeding para
  2. temperatureheat-refluxed for 4 hours
  3. additionThe reaction mixture was after-treated

Sources & evidence

ORD record
ord-69f847d9b4b64331bc51cefcaf71c876
Source dataset
uspto-grants-1992_09
Patent number
US05143935

Reaction notes

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