Acetic Anhydride → HCID 67895273, compound

HRID 1885499Notes

Reaction equation

HRID 1885499 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[NH2:8][C:9]1[CH:10]=[CH:11][C:12]([N:16]([C:20]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:21])[CH2:17][CH2:18][OH:19])=[C:13]([OH:15])[CH:14]=1>C(OCC)(=O)C>[OH2:3].[C:1]([NH:8][C:9]1[CH:10]=[CH:11][C:12]([N:16]([C:20]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:21])[CH2:17][CH2:18][OH:19])=[C:13]([OH:15])[CH:14]=1)(=[O:3])[CH3:2].[C:1]([NH:8][C:9]1[CH:10]=[CH:11][C:12]([N:16]([CH2:17][CH2:18][OH:19])[C:20]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:21])=[C:13]([OH:15])[CH:14]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 19878629HCID 19878629, compound

Product 1

HCID 67895273HCID 67895273, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
80 °C

Procedure

0.24 mole (23 ml) of acetic anhydride is added dropwise to a solution of 0.24 mole (72 g) of 5-amino-2-[N-benzyloxycarbonyl-N-(β-hydroxyethyl)amino]phenol in one liter of ethyl acetate heated to 80° C. After evaporation of the solvent under vacuum, the expected product is purified on a silica column. It then melts at 72° C.

Workup

  1. customAfter evaporation of the solvent under vacuum
  2. customthe expected product is purified on a silica column

Sources & evidence

ORD record
ord-eddfb0975ae34807b219d0c1fa92d54d
Source dataset
uspto-grants-1992_09
Patent number
US05145483

Reaction notes

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