Butylamine → HCID 19025862, compound

HRID 1885572Notes

Reaction equation

HRID 1885572 reaction equation
I[CH2:2][CH2:3][CH:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[OH:5].[CH2:12]([NH2:16])[CH2:13][CH2:14][CH3:15]>C1COCC1>[CH2:12]([NH:16][CH2:2][CH2:3][CH:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[OH:5])[CH2:13][CH2:14][CH3:15]

Participants

4

Reactant 2

HCID 8007ButylamineHCID 144768743-Iodo-1-phenylpropan-1-ol

Product 1

HCID 19025862HCID 19025862, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

(Compound 15) (12.5 g) was treated with butylamine (40 ml) in THF (75 ml) at RT for 4 h. The mixture evaporated and the residue extracted with OH- /ether. The ether phase washed with H2O and saturated NaCl-solution, dried (MgSO4) and evaporated giving 6.2 g of 3-butylamino-1-phenyl-1-propanol (compound 16). Identified by 1H NMR.

Workup

  1. customThe mixture evaporated
  2. extractionthe residue extracted with OH- /ether
  3. washThe ether phase washed with H2O and saturated NaCl-solution
  4. dry with materialdried (MgSO4)
  5. customevaporated

Sources & evidence

ORD record
ord-7d8142389cfc49c581c24b858c4ab23d
Source dataset
uspto-grants-1992_09
Patent number
US05145870

Reaction notes

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