Methylamine → HCID 15634838, compound

HRID 1885836Notes

Reaction equation

HRID 1885836 reaction equation
[CH3:1][NH2:2].[C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:13][C:12]([CH3:15])([CH3:14])[C@H:11]3[O:16][C@@H:10]3[C:9]=2[CH:17]=1)#[N:4]>C(O)C>[C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:13][C:12]([CH3:15])([CH3:14])[C@@H:11]([OH:16])[C@H:10]([NH:2][CH3:1])[C:9]=2[CH:17]=1)#[N:4]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 12139742HCID 12139742, compound

Product 1

HCID 15634838HCID 15634838, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of methylamine in dry ethanol was added to a solution of (3S,4R)-6-cyano-3,4-dihydro-3,4-epoxy-2,2-dimethyl-2H-1-benzopyran* (1.0 g) in dry ethanol, and the resulting solution stirred at room temperature for 2 days. Evaporation of solvent in vacuo gave the title compound as a gum (1.0 g) which was used without further purification.

Workup

  1. customEvaporation of solvent in vacuo

Sources & evidence

ORD record
ord-6bbc2a9263114a0f8b3dc3cd3c0a18e0
Source dataset
uspto-grants-1992_09
Patent number
US05147866

Reaction notes

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