Mandelic Acid → HCID 57182681, compound

HRID 1885837Notes

Reaction equation

HRID 1885837 reaction equation
[C:1]([OH:11])(=[O:10])[CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[OH:3].[CH2:12]([C:14]1[CH:15]=[CH:16][C:17]2[O:22][C:21]([CH3:24])([CH3:23])[C@@H:20](O)[C@H:19]([NH2:26])[C:18]=2[CH:27]=1)[CH3:13]>CC(O)C>[C:1]([O:11][C@H:20]1[C@H:19]([NH2:26])[C:18]2[CH:27]=[C:14]([CH2:12][CH3:13])[CH:15]=[CH:16][C:17]=2[O:22][C:21]1([CH3:23])[CH3:24])(=[O:10])[CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[OH:3]

Participants

4

Reactant 2

HCID 1292Mandelic AcidHCID 22845860HCID 22845860, compound

Product 1

HCID 57182681HCID 57182681, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

(+)-Mandelic acid (0.57 kg) and trans-6-ethyl-4-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ol** (0.75kg) were dissolved in warm 2-propanol (18 L). The solution was concentrated to 12 L and crystallised to give the title compound (0.523 kg).

Workup

  1. concentrationThe solution was concentrated to 12 L
  2. customcrystallised

Sources & evidence

ORD record
ord-1060d9e1c8d24d778589aeef2a132d1d
Source dataset
uspto-grants-1992_09
Patent number
US05147866

Reaction notes

Loading…