反应详情

A mixture of NaI (1.73 g, 11.57 mmol) and 2-butanone (20 mL) was heated under reflux for 30 minutes 1-N-(2-Chloroethyl)-2,3-dihydro-1H-imidazo[1,2-a]benzimidazole (1.70 g, 7.71 mmol) and additional 2-butanone (5 mL) were added and heating was continued for 5 hours. EtOAc (50 mL) was added and the mixture was filtered. The filtrate was washed with H2O, 10% sodium bisulfite (25 mL), saturated aqueous NaHCO3, dried (MgSO4) and concentrated to give 2.2 g (92%) of a light brown solid m.p. 101°-103° C.

1. temperaturewas heated
2. additionwere added
3. temperatureheating
4. filtrationthe mixture was filtered
5. washThe filtrate was washed with H2O, 10% sodium bisulfite (25 mL), saturated aqueous NaHCO3
6. dry with materialdried (MgSO4)
7. concentrationconcentrated