反应详情

A mixture of 6-benzyloxy-4-chromanone from Step 1 (5.68 g, 20 mmol), 3-carboxybenzaldehyde (30 g, 20 mmol), and 5N NaOH (10 ml, 50 mmol) in MeOH (200 ml) was stirred at r.t. for 9 days. The mixture was diluted with H2O (500 ml), acidified with HOAc to pH 5.6, filtered and air dried to give 7.95 g (98%) of the title compound.

1. filtrationfiltered
2. customair dried