4-Methoxyphenol → HCID 67741652, compound
Reaction equation
CO[C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.[N+]([C:13]1[CH:14]=[C:15]([C:21]#[N:22])[C:16](=[CH:19][CH:20]=1)[C:17]#[N:18])([O-])=O.[C:23](=O)([O-])[O-:24].[K+].[K+]>CN(C)C=O>[CH3:23][O:24][C:13]1[C:14]([O:9][C:6]2[CH:7]=[CH:8][CH:3]=[CH:4][CH:5]=2)=[C:15]([C:21]#[N:22])[C:16](=[CH:19][CH:20]=1)[C:17]#[N:18]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 70 °C
Procedure
A mixture was prepared by adding 136.4 grams (1.1 moles) of p-methoxyphenol, 173 grams (1 mole) of 4-nitrophthalonitrile, and 207 grams of potassium carbonate in 1667 ml of dimethylformamide. The mixture was heated to 70° C. and mechanically stirred. Samples were taken of this reaction mixture periodically and analyzed by GLC. After five hours, the reaction was complete. The p-methoxyphenoxyphthalonitrile was isolated by quenching the crude reaction mixture in ice water. The product was further purified by washing the crude precipitate with dilute sodium carbonate and then water. Finally the p-methoxyphenoxyphthalonitrile was vacuum dried at 60° C.
Workup
- customA mixture was prepared
Sources & evidence
- ORD record
- ord-66f15ff738004f3995a218750bd34c7d
- Source dataset
- uspto-grants-1992_09
- Patent number
- US05149800
Reaction notes
Loading…