Diethylamine → HCID 13504017, compound

HRID 1886141Notes

Reaction equation

HRID 1886141 reaction equation
[CH2:1]([N:8]1[CH2:12][CH:11]([CH2:13]Cl)[CH2:10][C:9]1=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:16]([NH:18][CH2:19][CH3:20])[CH3:17]>CN(C)C=O>[CH2:1]([N:8]1[CH2:12][CH:11]([CH2:13][N:18]([CH2:19][CH3:20])[CH2:16][CH3:17])[CH2:10][C:9]1=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 135040151-Benzyl-4-chloromethyl-pyrrolidin-2-one

Product 1

HCID 13504017HCID 13504017, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 14 g (0.06 mol) of crude 1-benzyl-4-chloromethyl-pyrrolidin-2-one, prepared as in Example 1(a), 10 g of diethylamine and 50 ml of dimethylformamide was stirred or shaken for 2 hours at 150° C. in an autoclave. The reaction mixture was evaporated to dryness in vacuo, the residue was taken up in methylene chloride, and the solution was washed first with water and finally the title compound was extracted twice with 25 ml of 2N HCl. The aqueous phase was separated, made alkaline with sodium hydroxide and the organic base was extracted with methylene chloride. The methylene chloride phase was evaporated, and the residue was distilled in vacuo.

Workup

  1. stirringshaken for 2 hours at 150° C. in an autoclave
  2. customThe reaction mixture was evaporated to dryness in vacuo
  3. washthe solution was washed first with water
  4. extractionfinally the title compound was extracted twice with 25 ml of 2N HCl
  5. customThe aqueous phase was separated
  6. extractionthe organic base was extracted with methylene chloride
  7. customThe methylene chloride phase was evaporated
  8. distillationthe residue was distilled in vacuo

Sources & evidence

ORD record
ord-bb6ccd7811d1451a88a358d0bb2b6c94
Source dataset
uspto-grants-1992_09
Patent number
US05149808

Reaction notes

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