Acetic Anhydride → N-(4-Iodophenyl)maleimide

HRID 1886155Notes

Reaction equation

[C:1]1(=[O:7])[NH:5][C:4](=[O:6])[CH:3]=[CH:2]1.[I:8][C:9]1[CH:15]=[CH:14][C:12](N)=[CH:11][CH:10]=1.C1(=O)OC(=O)C=C1.C(OC(=O)C)(=O)C.C([O-])(=O)C.[Na+]>>[I:8][C:9]1[CH:15]=[CH:14][C:12]([N:5]2[C:4](=[O:6])[CH:3]=[CH:2][C:1]2=[O:7])=[CH:11][CH:10]=1

Participants

Reactant 5

HCID 7918Acetic Anhydride

HCID 7923Maleic Anhydride

HCID 108934-Iodoaniline

HCID 10935Maleimide

HCID 517045Sodium Acetate

Product 1

HCID 96758N-(4-Iodophenyl)maleimide

Procedure

The title compound was prepared by standard maleimide procedures involving the reaction of p-iodoaniline with maleic anhydride and then subsequent cyclization with acetic anhydride and sodium acetate.

Sources & evidence

ORD record: ord-b218e69ed7dc4e4792a0e0cc077ed650
Source dataset: uspto-grants-1992_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05149824

Reaction notes

Loading…