反应详情

Into a solution of 2.51 g (9.2 mmol) of 6-methoxy-2-naphthyl bromide in 31 ml of diethylamine distilled with calcium hydride were charged 324 mg (0.46 mmol) of bistriphenylphosphine palladium dichloride and 192 mg of cupric iodide (1.01 mmol), followed by stirring. To the mixture was gradually added 1.06 g (9.4 mmol) of methyl 5-hexynoate, and the mixture was stirred at room temperature overnight (about 15 hours). Diethylamine was evaporated under a reduced pressure, to the residue were added ethyl acetate and water, and the mixture was extracted with ethyl acetate. Anhydrous magnesium sulfate was introduced into the organic layer for drying.

1. stirringthe mixture was stirred at room temperature overnight (about 15 hours)
2. customDiethylamine was evaporated under a reduced pressure, to the residue
3. additionwere added ethyl acetate and water
4. extractionthe mixture was extracted with ethyl acetate
5. additionAnhydrous magnesium sulfate was introduced into the organic layer
6. customfor drying