Acetic Acid → HCID 14601681, compound

HRID 1886322Notes

Reaction equation

HRID 1886322 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][C:6]([CH:7]=O)=[CH:5][CH:4]=1.NC1C=CC([N:20]2[C:25](=[O:26])[CH2:24][CH2:23][CH:22]=[N:21]2)=CC=1.[C:27](O)(=O)[CH3:28].C[N:32](C)[C:33](=O)[CH3:34].[CH2:37](O)[CH3:38]>>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][C:6]([CH:7]=[N:32][C:33]2[CH:34]=[CH:28][C:27]([C:22]3[CH2:23][CH2:24][C:25](=[O:26])[NH:20][N:21]=3)=[CH:38][CH:37]=2)=[CH:5][CH:4]=1

Participants

6

Reactant 5

HCID 176Acetic AcidHCID 702EthanolHCID 31374DimethylacetamideHCID 679964-(Trifluoromethyl)benzaldehydeHCID 20326490HCID 20326490, compound

Product 1

HCID 14601681HCID 14601681, compound

Procedure

A solution containing 0.87 g of 4-trifluoromethylbenzaldehyde, 6-(4-aminophenyl-4,5-dihydropyridazin-3(2H)one, 1 ml of acetic acid and 10 ml of N,N-dimethylacetamide in 40 ml of ethanol was refluxed for 5 h. The product was filtered and washed with ethanol. Yield 0.7 g (41%), m.p. 245°-247° C.

Workup

  1. filtrationThe product was filtered
  2. washwashed with ethanol

Sources & evidence

ORD record
ord-fbc38182c0df4a9d978321fa73d383c0
Source dataset
uspto-grants-1992_09
Patent number
US05151420

Reaction notes

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