Phenacyl bromide → HCID 19875819, compound

HRID 1886324Notes

Reaction equation

HRID 1886324 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]([CH3:16])[CH2:11][C:12](=[O:15])[NH:13][N:14]=2)[CH:5]=[CH:6][C:7]=1[NH2:8].[CH2:17](Br)[C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=O.C([O-])(=O)C.[Na+]>C(O)C>[CH3:16][CH:10]1[C:9]([C:4]2[CH:3]=[C:2]3[C:7](=[CH:6][CH:5]=2)[NH:8][CH:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:17][NH:1]3)=[N:14][NH:13][C:12](=[O:15])[CH2:11]1

Participants

5

Reactant 3

HCID 6259Phenacyl bromideHCID 517045Sodium AcetateHCID 34410526-(3,4-Diaminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one

Product 1

HCID 19875819HCID 19875819, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution containing 0.3 g of 6-(3,4-diaminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)one, 0.3 g of phenacyl bromide and 0.14 g of sodium acetate in 2.6 ml of ethanol was stirred for 3.5 h at room temperature. The product was washed with water and ethanol. Yield 0.1 g (23%), m.p. 209°-215° C.

Workup

  1. washThe product was washed with water and ethanol

Sources & evidence

ORD record
ord-701059384d6047d08d962f2814405ea2
Source dataset
uspto-grants-1992_09
Patent number
US05151420

Reaction notes

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