HRID1886458

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

HCID167693

未命名化合物

结构：CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(N)=O)c1

HCID19876062

未命名化合物

HCID21226206

未命名化合物

PRODUCTS

生成物

结构：CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)NC)c1

HCID19804279

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of 12.1 mg of the product of Example 6 in CH2Cl2 at 0° C. was added 0.2 mL of 10% trimethylsilyl-diazomethane. After stirring for 10 minutes, 0.2 mL of acetic acid was added. The volatiles were removed in vacuo. The product was isolated using preparative TLC with 1:1 hexane/ethyl acetate.

WORKUP

后处理

customThe volatiles were removed in vacuo
customThe product was isolated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8dd9dc7e23644de09511b7668afd1d68
来源数据集: uspto-grants-1992_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05151435
来源说明: uspto-grants-1992_09

反应 SMILES

[C:1]([C:4]1[CH:34]=[CH:33][CH:32]=[CH:31][C:5]=1[C:6]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([CH2:17][N:18]3[C:22]4=[N:23][C:24]([CH3:28])=[CH:25][C:26]([CH3:27])=[C:21]4[N:20]=[C:19]3[CH2:29][CH3:30])=[CH:14][CH:15]=2)[CH:10]=[CH:9]1)=[O:7])(=[O:3])[NH2:2].[CH3:35][Si](C=[N+]=[N-])(C)C.C(O)(=O)C.CCCCCC.C(OCC)(=O)C>C(Cl)Cl>[CH3:35][NH:2][C:1]([C:4]1[CH:34]=[CH:33][CH:32]=[CH:31][C:5]=1[C:6]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([CH2:17][N:18]3[C:22]4=[N:23][C:24]([CH3:28])=[CH:25][C:26]([CH3:27])=[C:21]4[N:20]=[C:19]3[CH2:29][CH3:30])=[CH:14][CH:15]=2)[CH:10]=[CH:9]1)=[O:7])=[O:3]