Triethylamine → HCID 178513962, compound

HRID 1886492Notes

Reaction equation

HRID 1886492 reaction equation
Br.Br.[NH2:3][C@H:4]([C:11]([N:13]1[CH2:20][CH2:19][CH2:18][C@H:14]1[C:15]([NH2:17])=[O:16])=[O:12])[CH2:5][C:6]1[N:10]=[CH:9][NH:8][CH:7]=1.C(N(CC)CC)C>CN(C=O)C>[NH2:3][C@H:4]([C:11]([N:13]1[CH2:20][CH2:19][CH2:18][C@H:14]1[C:15]([NH2:17])=[O:16])=[O:12])[CH2:5][C:6]1[N:10]=[CH:9][NH:8][CH:7]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 178419276HCID 178419276, compound

Product 1

HCID 178513962HCID 178513962, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

L-Histidyl-L-prolinamide dihydrobromide (4.33 g) was dissolved in DMF (15 ml), and triethylamine (2.92 ml) was added to the solution under cooling at <10° C. After the mixture was stirred under ice-cooling for 10 minutes, the resulting precipitation was filtered off to give a DMF solution of L-histidyl-L-prolinamide, which was immediately used in the following synthetic reaction.

Workup

  1. temperatureunder cooling at <10° C
  2. temperaturecooling for 10 minutes
  3. customthe resulting precipitation
  4. filtrationwas filtered off

Sources & evidence

ORD record
ord-50412d6638a0423c8e793a82774a4ee1
Source dataset
uspto-grants-1992_09
Patent number
US05151497

Reaction notes

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