Triethylamine → HCID 58341775, compound

HRID 1886764Notes

Reaction equation

HRID 1886764 reaction equation
C(N(CC)CC)C.[C:8](Cl)(=[O:12])[C:9]([CH3:11])=[CH2:10].[CH:14]1[C:19]2[CH2:20][CH2:21][CH2:22][CH2:23][CH:24]([OH:25])[C:18]=2[CH:17]=[CH:16][CH:15]=1>C1(C)C=CC=CC=1>[C:8]([O:25][CH:24]1[C:18]2[CH:17]=[CH:16][CH:15]=[CH:14][C:19]=2[CH2:20][CH2:21][CH2:22][CH2:23]1)(=[O:12])[C:9]([CH3:11])=[CH2:10]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 13528Methacryloyl chlorideHCID 371715H-Benzocyclohepten-5-ol, 6,7,8,9-tetrahydro-

Product 1

HCID 58341775HCID 58341775, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

With stirring and ice cooling, 111 g of triethylamine was added to a mixture of 120 g of methacrylic acid chloride, 240 g of 6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol, and 1500 g of toluene. The mixture was stirred at room temperature for 16 hours. By standard aqueous work-up and solvent distillation, a crude product was obtained. It was purified by column chromatography, yielding the target compound, 6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yl methacrylate.

Workup

  1. stirringThe mixture was stirred at room temperature for 16 hours
  2. distillationBy standard aqueous work-up and solvent distillation
  3. customa crude product was obtained
  4. customIt was purified by column chromatography

Sources & evidence

ORD record
ord-d5e9550cd5d44f6fab851a603c5d5035
Source dataset
uspto-grants-2013_08
Patent number
US08501384B2

Reaction notes

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