N-methyl-2-pyrrolidone → NMP Methanol

HRID 1886768Notes

Reaction equation

HRID 1886768 reaction equation
[CH3:1][N:2]1[C:6](=[O:7])[CH2:5][CH2:4][CH2:3]1.CN1[C:14](=[O:15])N(C)CCC1.C1C2NC=C(O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)C=2C(Cl)=C(Br)C=1>CO>[CH3:1][N:2]1[C:6](=[O:7])[CH2:5][CH2:4][CH2:3]1.[CH3:14][OH:15]

Participants

5

Reactant 3

HCID 13387N-methyl-2-pyrrolidone2×HCID 65181X-GalHCID 816462(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl-2×

Product 1

HCID 22395687NMP Methanol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Add 7 ml of either NMP or DMPU to 1 gram of X-gal and stir until dissolved. Bring to 10 ml with NMP or DMPU (whichever is already used). Add 90 ml of methanol and mix thoroughly.

Workup

  1. dissolutionuntil dissolved
  2. additionmix thoroughly

Sources & evidence

ORD record
ord-fa8b2da9e62f41dda81297dcad4f1235
Source dataset
uspto-grants-2013_08
Patent number
US08501433B2

Reaction notes

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