反应详情

温度

80 °C

To 5-Nitro-2-phenylbenzofuran (250 mg, 1.04 mmol) in ethanol/water 2:1 v/v (12 mL) at 80° C. was added ammonium chloride (112 mg, 2.09 mmol) and iron powder (292 mg, 5.23 mmol). The resulting mixture was heated at 80° C. for 4 h. After cooling, the solution was filtrated through a pad of Celite®, which was washed with ethanol. The organic layer was evaporated into vacuo to obtain a solid, which was then taken up in ethyl acetate and washed with water. The combined organic layers were dried over anhydrous MgSO4 and evaporated to afford 211 mg (96%) of the title compound.

1. temperatureAfter cooling
2. filtrationthe solution was filtrated through a pad of Celite®, which
3. washwas washed with ethanol
4. customThe organic layer was evaporated into vacuo
5. customto obtain a solid, which
6. washwashed with water
7. dry with materialThe combined organic layers were dried over anhydrous MgSO4
8. customevaporated