Picolinic acid → HCID 44160106, compound

HRID 1886970Notes

Reaction equation

HRID 1886970 reaction equation
[NH2:1][CH:2]1[C:8]2=[N:9][C:10]([C:14]3[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=3)=[CH:11][C:12](=[O:13])[N:7]2[CH2:6][CH2:5][O:4][CH2:3]1.[N:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[C:26](O)=[O:27].C(OC(N1CCC2C(=CC(C(O)=O)=CC=2)C1)=O)(C)(C)C>>[O:13]=[C:12]1[N:7]2[C:8]([CH:2]([NH:1][C:26]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][N:20]=3)=[O:27])[CH2:3][O:4][CH2:5][CH2:6]2)=[N:9][C:10]([C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)=[CH:11]1

Participants

4

Reactant 3

HCID 1018Picolinic acidHCID 189883742-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acidHCID 66846193(+/-) 9-Amino-2-pyridin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4a-diaza-benzocyclohepten-4-one

Product 1

HCID 44160106HCID 44160106, compound

Procedure

By analogy with the method described in example 1 (step 1.4), using (+/−) 9-amino-2-pyridin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4-a-diaza-benzocyclohepten-4-one and 2-pyridine carboxylic acid in place of (+/−)-9-amino-2-pyrimidin-4-yl-5,6,8,9-tetrahydro-7-oxa-1,4-a-diaza-benzocyclohepten-4-one and 3,4-dihydro-1H-isoquinoline-2,7-dicarboxylic acid 2-tert-butyl ester, the compound, 0.035 g (57%), was obtained as a white powder.

Workup

  1. customthe compound, 0.035 g (57%), was obtained as a white powder

Sources & evidence

ORD record
ord-444fd4050cd14a2294470e79c2ebdccb
Source dataset
uspto-grants-2013_08
Patent number
US08501728B2

Reaction notes

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