Hydrochloric Acid → HCID 131730790, compound

HRID 1887480Notes

Reaction equation

HRID 1887480 reaction equation
C(OC([N:8]1[CH2:16][CH:15]2[CH:10]([C:11](=[O:28])[N:12]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=3)[CH2:13][CH2:14]2)[CH2:9]1)=O)(C)(C)C.[ClH:29]>C(OCC)(=O)C>[ClH:29].[F:27][C:24]([F:25])([F:26])[O:23][C:20]1[CH:21]=[CH:22][C:17]([N:12]2[CH2:13][CH2:14][CH:15]3[CH2:16][NH:8][CH2:9][CH:10]3[C:11]2=[O:28])=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71008751HCID 71008751, compound

Product 1

HCID 131730790HCID 131730790, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4-oxo-5-(4-trifluoromethoxy-phenyl)-octahydro-pyrrolo[3,4-c]pyridine-2-carboxylic acid tert-butyl ester (900 mg, 2.25 mmol) was added to a solution of saturated hydrochloride in ethyl acetate (4 mL). The reaction mixture was stirred at ambient temperature overnight. The solvent was removed under reduced pressure, then the crude product (800 mg) was obtained which was used without further purification. 1H NMR (300 MHz, d6-DMSO): δ 7.51-7.38 (m, 4H), 3.79-3.25 (m, 6H), 3.04-3.01 (m, 1H), 2.84-2.81 (m, 1H), 2.06-2.03 (m, 1H), 1.82-1.80 (m, 1H); LC-MS: [M+1]+ 302.7.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-04861872e6f64b579a281aba8fb1b133
Source dataset
uspto-grants-2013_08
Patent number
US08501768B2

Reaction notes

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