反应详情

温度

55 °C

(2R)-2-(2-Amino-2-methylpropanamido)-4-methyl-N-[2-oxo-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl]pentanamide (1.5 g) was dissolved in isopropyl acetate (68.5 mL), and 4N hydrochloric acid in ethyl acetate (0.95 mL) was added thereto. The mixture was stirred at 55° C. for one hour, and then left to stand to cool to room temperature. The formed precipitates were recovered through filtration, washed with isopropyl acetate, and dried under reduced pressure, whereby the title compound (1.47 g) was yielded.

1. waitleft
2. temperatureto cool to room temperature
3. customThe formed precipitates
4. filtrationwere recovered through filtration
5. washwashed with isopropyl acetate
6. dry with materialdried under reduced pressure, whereby the title compound (1.47 g)
7. customwas yielded