反应详情

In a 25 mL round-bottomed flask, 4-nitrophenyl (7-chloro-4-oxo-1-phenyl-1,4-dihydroquinolin-3-yl)methylcarbamate (intermediate M) (0.05 g, 0.111 mmol), 1-phenylpiperazine (18.0 mg, 0.111 mmol) and N,N-diisopropylethylamine (43.1 mg, 58.2 μA, 333 mmol) were combined with methylene chloride (5 mL). The reaction mixture was stirred at room temperature. The crude product was purified using preparative reverse-phase HPLC, giving 4-phenyl-piperazine-1-carboxylic acid (7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-amide MS calcd. for C27H26ClN4O2 [(M+H)+] 473.2, obsd. 473.0.

1. customThe crude product was purified