Donepezil → HCID 86648412, compound

HRID 1888020Notes

Reaction equation

HRID 1888020 reaction equation
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7]([OH:10])(=[O:9])=[O:8])=[CH:3][CH:2]=1.[CH3:12][O:13][C:14]1[CH:15]=[C:16]2[CH2:25][CH:24]([CH2:26][CH:27]3[CH2:32][CH2:31][N:30]([CH2:33][C:34]4[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=4)[CH2:29][CH2:28]3)[C:22](=[O:23])[C:17]2=[CH:18][C:19]=1[O:20][CH3:21]>C(OCC)(=O)C>[CH3:12][O:13][C:14]1[CH:15]=[C:16]2[CH2:25][CH:24]([CH2:26][CH:27]3[CH2:28][CH2:29][N:30]([CH2:33][C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)[CH2:31][CH2:32]3)[C:22](=[O:23])[C:17]2=[CH:18][C:19]=1[O:20][CH3:21].[C:1]1([CH3:11])[CH:2]=[CH:3][C:4]([S:7]([O-:10])(=[O:8])=[O:9])=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 3152DonepezilHCID 6101p-Toluenesulfonic acid

Product 1

HCID 86648412HCID 86648412, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Para-toluenesulfonic acid (1.902 g, dissolved in 35 ml of absolute ethanol) is slowly added to a solution of Donepezil (3.79 g) in ethyl acetate (70 ml) with stirring at room temperature. The solid precipitated is filtered and dried at 55° C. under vacuum to give the title compound. Melting point: 170.8° C.

Workup

  1. customThe solid precipitated
  2. filtrationis filtered
  3. customdried at 55° C. under vacuum

Sources & evidence

ORD record
ord-e0bb884b95174d1dbf2bfc1032a1bb8d
Source dataset
uspto-grants-2013_08
Patent number
US08501779B2

Reaction notes

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