Malic Acid → HCID 86648417, compound

HRID 1888068Notes

Reaction equation

HRID 1888068 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[CH2:14][CH:13]([CH2:15][CH:16]3[CH2:21][CH2:20][N:19]([CH2:22][C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH2:18][CH2:17]3)[C:11](=[O:12])[C:6]2=[CH:7][C:8]=1[O:9][CH3:10].[C:29]([OH:37])(=[O:36])[CH:30]([CH2:32][C:33]([OH:35])=[O:34])[OH:31]>C(OCC)(=O)C.C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[CH2:14][CH:13]([CH2:15][CH:16]3[CH2:17][CH2:18][N:19]([CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH2:20][CH2:21]3)[C:11](=[O:12])[C:6]2=[CH:7][C:8]=1[O:9][CH3:10].[C:29]([O-:37])(=[O:36])[CH:30]([CH2:32][C:33]([O-:35])=[O:34])[OH:31]

Participants

5

Reactant 2

HCID 525Malic AcidHCID 3152Donepezil

Product 1

HCID 86648417HCID 86648417, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

1.901 g of Donepezil is dissolved in 15 ml of ethyl acetate. A solution (4 ml) of malic acid (0.679 g) in absolute ethanol is added slowly and drop-wisely and the resulted solution is stirred. The solid precipitated is filtered with suction to give the title compound.

Workup

  1. customThe solid precipitated
  2. filtrationis filtered with suction

Sources & evidence

ORD record
ord-714632594a5f453690dc684c51d0e3ad
Source dataset
uspto-grants-2013_08
Patent number
US08501779B2

Reaction notes

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