Aspirin → HCID 86648420, compound

HRID 1888075Notes

Reaction equation

HRID 1888075 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[CH2:14][CH:13]([CH2:15][CH:16]3[CH2:21][CH2:20][N:19]([CH2:22][C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH2:18][CH2:17]3)[C:11](=[O:12])[C:6]2=[CH:7][C:8]=1[O:9][CH3:10].[C:29]([O:32][C:33]1[C:34](=[CH:38][CH:39]=[CH:40][CH:41]=1)[C:35]([OH:37])=[O:36])(=[O:31])[CH3:30]>C(OCC)(=O)C.CC(C)=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[CH2:14][CH:13]([CH2:15][CH:16]3[CH2:17][CH2:18][N:19]([CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH2:20][CH2:21]3)[C:11](=[O:12])[C:6]2=[CH:7][C:8]=1[O:9][CH3:10].[C:29]([O:32][C:33]1[C:34](=[CH:38][CH:39]=[CH:40][CH:41]=1)[C:35]([O-:37])=[O:36])(=[O:31])[CH3:30]

Participants

5

Reactant 2

HCID 2244AspirinHCID 3152Donepezil

Product 1

HCID 86648420HCID 86648420, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 8857Ethyl AcetateSolvent

Procedure

3.79 g of Donepezil is dissolved in 70 ml of ethyl acetate, and a solution of acetylsalicylic acid (1.80 g) in acetone (35 ml) is added slowly with stirring at room temperature. The solid precipitated is filtered. Melting point: 173-176° C.

Workup

  1. customThe solid precipitated
  2. filtrationis filtered

Sources & evidence

ORD record
ord-5d80dd6e7df542c782ebd38dcc1483a3
Source dataset
uspto-grants-2013_08
Patent number
US08501779B2

Reaction notes

Loading…