反应详情

Anhydrous cerium chloride (0.99 g, 4.0 mmol) and sodium iodide (1.8 g, 12.0 mmol) are added to 10 ml of anhydrous tetrahydrofuran as a solvent to form a suspension. Dissolving 0.87 g (4.0 mmol) of 2-bromo-1-(4-fluorophenyl)-ethanone and 0.76 g (4.0 mmol) of N-benzyl-4-piperidone in 10 ml of anhydrous tetrahydrofuran, and the solution is added dropwise to the above suspension and reacting at room temperature for 2 hours. Operating according to the post-treatment procedure in General Method three, and a salt is formed by acidifying with hydrobromic acid/ethanol solution, which is recrystallized in ethyl acetate/ethanol to obtain 0.58 g of a white crystal, with yield of 34.0%.

1. customto form a suspension
2. additionthe solution is added dropwise to the above suspension
3. customa salt is formed
4. customis recrystallized in ethyl acetate/ethanol