Sodium Iodide → HCID 67119884, compound

HRID 1888084Notes

Reaction equation

HRID 1888084 reaction equation
[Cl-].[Ce+3].[Cl-].[Cl-].[I-].[Na+].[Br:7][CH2:8][C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)=[O:10].[CH2:17]([N:24]1[CH2:29][CH2:28][C:27](=[O:30])[CH2:26][CH2:25]1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>O1CCCC1>[BrH:7].[CH2:17]([N:24]1[CH2:29][CH2:28][C:27]([CH2:8][C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)=[O:10])([OH:30])[CH2:26][CH2:25]1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

6

Reactant 4

HCID 5238Sodium IodideHCID 192201-Benzyl-4-piperidoneHCID 24636Cerium(III) chlorideHCID 383842-Bromoacetamidopyridine

Product 1

HCID 67119884HCID 67119884, compoundYield 36.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Anhydrous cerium chloride (0.99 g, 4.0 mmol) and sodium iodide (1.8 g, 12.0 mmol) are added to 10 ml of anhydrous tetrahydrofuran as a solvent to form a suspension. Dissolving 0.80 g (4.0 mmol) of 2-bromo-1-(2-pyridyl)-ethanone and 0.76 g (4.0 mmol) of N-benzyl-4-piperidone into 10 ml of anhydrous tetrahydrofuran, and the solution is added dropwise to the above suspension and reacting at room temperature for 2 hours. Operating according to the post-treatment procedure in General Method three to obtain 0.53 g of a white crystal, with yield of 36.3%.

Workup

  1. customto form a suspension
  2. additionthe solution is added dropwise to the above suspension

Sources & evidence

ORD record
ord-f0ad8ba503944b42b8b00d3944beb137
Source dataset
uspto-grants-2013_08
Patent number
US08501778B2

Reaction notes

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