Potassium Carbonate → HCID 58047521, compound

HRID 1888735Notes

Reaction equation

HRID 1888735 reaction equation
[Cl:1][C:2]1[C:3]([O:11][CH2:12][O:13][CH3:14])=[CH:4][C:5]([OH:10])=[C:6]([CH:9]=1)[CH:7]=O.Br[CH2:16][C:17](=[O:19])[CH3:18].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Cl:1][C:2]1[C:3]([O:11][CH2:12][O:13][CH3:14])=[CH:4][C:5]2[O:10][C:16]([C:17](=[O:19])[CH3:18])=[CH:7][C:6]=2[CH:9]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 11715BromoacetoneHCID 57425030HCID 57425030, compound

Product 1

HCID 58047521HCID 58047521, compoundYield 72.4%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Using 5-chloro-2-hydroxy-4-(methoxymethoxy)benzaldehyde (1.50 g, 6.94 mmol), acetonitrile (14 mL), bromoacetone (1.57 g, 10.4 mmol) and potassium carbonate (2.87 g, 20.8 mmol), an operation in the same manner as in Reference Example 86 was performed to give the title compound (1.28 g, yield 72%).

Sources & evidence

ORD record
ord-7859d80167c849ba9e0111bb279cf8dc
Source dataset
uspto-grants-2013_08
Patent number
US08501804B2

Reaction notes

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