HRID1888830
反应详情
EQUATION
反应方程式
REACTANTS
反应物
HCID31374
Dimethylacetamide
C4H9NO
HCID2733084
Methanaminium, N-[(1H-benzotriazol-1-yloxy)(dimethylamino)methylene]-N-methyl-, hexafluorophosphate(1-) (1:1)
C11H16F6N5OP
HCID59455875
未命名化合物
HCID66725223
(5-methanesulfonylpyridin-2-yl)methanaminium chloride;[5-(methanesulfonyl)pyridin-2-yl]methanaminium chloride
C7H11ClN2O2S
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
HBTU (30 mg, 0.079 mmol) was added to {[5-(methylsulfonyl)pyridin-2-yl]methyl}amine hydrochloride (20 mg, 0.090 mmol), 6-methyl-5-(2-methyl-2H-pyrazol-3-yl)-2-oxo-1-(3-trifluoromethyl-phenyl)-1,2-dihydro-pyridine-3-carboxylic acid (Example 92 (a), 27 mg, 0.072 mmol) and DMA (23 μl, 0.31 mmol) in NMP (0.25 ml) and the mixture was stirred in a sealed vial overnight. The product was purified by preparative HPLC and freeze-dried to give the title compound as a white solid (8 mg, 20%).
WORKUP
后处理
- customThe product was purified by preparative HPLC
- customfreeze-dried