反应详情

温度

100 °C

To a suspension of N-(5-methyl-2-nitrophenyl)benzamide (3 mmol) in isopropanol (150 mL) was added iron powder (2 g) and ammonium chloride (0.3 mmol). The reaction mixture was heated at 100° C. for 12 h. The hot mixture was filtered off and the filtrate was evaporated. The residue was subjected to flash chromatography on silica gel using a mixture of hexanes and CH2Cl2 (9:1) as eluent to afford N-(2-amino-5-methylphenyl)benzamide as a white-gray solid.

1. filtrationThe hot mixture was filtered off
2. customthe filtrate was evaporated
3. additiona mixture of hexanes and CH2Cl2 (9:1) as eluent