反应详情

2,3-dichloro-4-fluorobenzoic acid (I32) (5.76 g, 27.6 mmol) was suspended in dichloromethane (DCM) (150 mL) at 0° C. and treated with oxalyl chloride (2.89 mL, 33.1 mmol). The mixture was stirred at 0° C. for 10 minutes before 5 drops of DMF were added. The mixture was stirred to room temperature over 4 h. Solvents were removed in vacuo and the residue was azeotroped with toluene (3×100 mL). The residue was used directly in subsequent steps without further purification, assuming 100% yield.

1. additionwere added
2. customSolvents were removed in vacuo
3. customthe residue was azeotroped with toluene (3×100 mL)
4. customThe residue was used directly in subsequent steps without further purification