反应详情

3-chloro-4-fluoro-2-methylbenzoic acid (I57)(0.754 g, 4 mmol) in dichloromethane (DCM) (30 mL) was cooled to 0° C., before oxalyl chloride (0.385 mL, 4.40 mmol) and a few drops of DMF (cat.) were added. The solution was then stirred under argon for 3 hours, before the solvent was evaporated in vacuo. The remaining residue was then azeotroped with toluene to yield the product in 0.819 g.

1. additionwere added
2. customwas evaporated in vacuo
3. customThe remaining residue was then azeotroped with toluene
4. customto yield the product in 0.819 g