Morpholine → HCID 59301285, compound

Temperature

60 °C

To a mixture of 2-amino-5- bromothiazole monohydrobromide (2 gm, 7.69 mmol) and powdered potassium carbonate (2.1 gm, 15.38 mmol) in DMF (20 mL) was added morpholine (1.34 ml, 15.38 mmol) under argon atmosphere and heated at 60° C. for 3 hr. Reaction mixture was cooled to rt and poured over ice cold water (100 ml), extracted with ethylacetate (3×100 ml), washed with brine solution, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. To the residue, diisopropyl ether (50 mL) was added, after stirring for 30 minutes product precipitated out, which was filtered and dried under vacuum to provide 5-morpholin-4-yl-thiazol-2-ylamine (0.95 gm).

1. customReaction mixture
2. temperaturewas cooled to rt
3. extractionextracted with ethylacetate (3×100 ml)
4. washwashed with brine solution
5. dry with materialdried over anhydrous sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure
8. additionTo the residue, diisopropyl ether (50 mL) was added
9. customprecipitated out
10. filtrationwhich was filtered
11. customdried under vacuum

ORD record

ord-da9bacf071b041a2a9191392bcbfb562

Source dataset

uspto-grants-2013_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08501955B2