反应详情

To a solution of 2,4-difluorophenol in acetonitrile, was added potassium carbonate followed by bromo-(4-cyclopropanesulfonyl-phenyl)-acetic acid ethyl ester (obtained in step I) and stirred for 10-14 hours. After completion, the reaction mixture was filtered; the filtrate was concentrated to obtain a residue which was dissolved in ethyl acetate; this solution was washed with water followed by brine solution, dried over anhydrous sodium sulfate, solvent was removed under reduced pressure to provide a crude product which was purified by column chromatography to provide the compound A1-II.

1. filtrationAfter completion, the reaction mixture was filtered
2. concentrationthe filtrate was concentrated
3. customto obtain a residue which
4. washthis solution was washed with water
5. dry with materialdried over anhydrous sodium sulfate, solvent
6. customwas removed under reduced pressure