Lithium Hydroxide → HCID 59610055, compound

HRID 1889203Notes

Reaction equation

HRID 1889203 reaction equation
C[O:2][C:3](=[O:41])[C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[S:15][C:14]([NH:16][C:17](=[O:40])[CH:18]([C:28]3[CH:33]=[CH:32][C:31]([S:34]([CH:37]4[CH2:39][CH2:38]4)(=[O:36])=[O:35])=[CH:30][CH:29]=3)[O:19][C:20]3[CH:25]=[CH:24]C(F)=[CH:22][C:21]=3F)=[N:13][CH:12]=2)=[CH:6][CH:5]=1.[Li+].[OH-:43]>C1COCC1.CO.O>[CH:37]1([S:34]([C:31]2[CH:32]=[CH:33][C:28]([CH:18]([O:19][CH:20]3[CH2:25][CH2:24][O:43][CH2:22][CH2:21]3)[C:17]([NH:16][C:14]3[S:15][C:11]([O:10][C:7]4[CH:6]=[CH:5][C:4]([C:3]([OH:2])=[O:41])=[CH:9][CH:8]=4)=[CH:12][N:13]=3)=[O:40])=[CH:29][CH:30]=2)(=[O:36])=[O:35])[CH2:38][CH2:39]1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 56592434HCID 56592434, compound

Product 1

HCID 59610055HCID 59610055, compoundYield 72.2%

Reagents, catalysts & solvents 1

HCID 21892291Methanol tetrahydrofuran waterSolvent

Procedure

The compound of example B29 was obtained by similar method described in example B28 using 4-{2-[2-(4-Cyclopropanesulfonyl-phenyl)-2-(2,4-difluoro-phenoxy)-acetylamino]-thiazol-5-yloxy}-benzoic acid methyl ester (0.17 g, 0.29 mmol), LiOH (0.062 g, 1.48 mmol) in THF: MeOH: Water (1:1:1, 9 mL) to provide the title compound (0.117 g, 72%).

Workup

  1. customwas obtained by similar method

Sources & evidence

ORD record
ord-8cefe7646927455e8128cb3279652195
Source dataset
uspto-grants-2013_08
Patent number
US08501955B2

Reaction notes

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