Lithium Hydroxide → HCID 56592348, compound

HRID 1889204Notes

Reaction equation

HRID 1889204 reaction equation
C[O:2][C:3](=[O:38])[C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[S:15][C:14]([NH:16][C:17](=[O:37])[CH:18]([C:25]3[CH:30]=[CH:29][C:28]([S:31]([CH:34]4[CH2:36][CH2:35]4)(=[O:33])=[O:32])=[CH:27][CH:26]=3)[O:19][C@@H:20]3[CH2:24][CH2:23][O:22][CH2:21]3)=[N:13][CH:12]=2)=[CH:6][CH:5]=1.[Li+].[OH-]>C1COCC1.CO.O>[CH:34]1([S:31]([C:28]2[CH:29]=[CH:30][C:25]([CH:18]([O:19][C@@H:20]3[CH2:24][CH2:23][O:22][CH2:21]3)[C:17]([NH:16][C:14]3[S:15][C:11]([O:10][C:7]4[CH:8]=[CH:9][C:4]([C:3]([OH:38])=[O:2])=[CH:5][CH:6]=4)=[CH:12][N:13]=3)=[O:37])=[CH:26][CH:27]=2)(=[O:33])=[O:32])[CH2:36][CH2:35]1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 56592267HCID 56592267, compound

Product 1

HCID 56592348HCID 56592348, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 21892291Methanol tetrahydrofuran waterSolvent

Procedure

The compound of example B30 was obtained by similar method described in example B28 using 4-(2-{2-(4-Cyclopropanesulfonyl-phenyl)-2-[(R)-(tetrahydro-furan-3-yl)oxy]-acetylamino}-thiazol-5-yloxy)-benzoic acid methyl ester (0.180 g, 0.32mmol), LiOH (0.067 g, 1.61 mmol) in THF: MeOH: Water (1:1:1, 9 mL) to provide the title compound (0.160 mg, 92%).

Workup

  1. customwas obtained by similar method

Sources & evidence

ORD record
ord-962f66a771af4303bd54d587265606e5
Source dataset
uspto-grants-2013_08
Patent number
US08501955B2

Reaction notes

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