反应详情

To 22.81 g cesium carbonate and 7.08 g methyl 1-hydroxy-2-naphthoate in 70 ml abs. DMF was added 7.39 g (2-bromo-ethoxy)-benzene and the mixture was reacted for 16 h at 80° C. The reaction was poured unto ice, neutralized with 2 M hydrochloric acid, and extracted with ethyl acetate twice. The combined organic phases were washed with brine, dried over magnesium sulphate and concentrated in vacuo. The resulting residue was purified by crystallization from pentane to yield 9.60 g of 1-(2-phenoxy-ethoxy)-naphthalene-2-carboxylic acid methyl ester.

1. customthe mixture was reacted for 16 h at 80° C
2. additionThe reaction was poured unto ice
3. extractionextracted with ethyl acetate twice
4. washThe combined organic phases were washed with brine
5. dry with materialdried over magnesium sulphate
6. concentrationconcentrated in vacuo
7. customThe resulting residue was purified by crystallization from pentane