Hydrochloric Acid → HCID 136348338, compound

HRID 1889447Notes

Reaction equation

HRID 1889447 reaction equation
[CH2:1]([C:3]1[S:40][C:6]2[N:7]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=4[C:34]4[NH:38][C:37](=[O:39])[O:36][N:35]=4)=[CH:24][CH:23]=3)[C:8](=[O:20])[N:9]([CH2:12][CH2:13][N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)[C:10](=[O:11])[C:5]=2[CH:4]=1)[CH3:2].[ClH:41]>C(OCC)(=O)C.CC(C)=O>[ClH:41].[CH2:1]([C:3]1[S:40][C:6]2[N:7]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=4[C:34]4[NH:38][C:37](=[O:39])[O:36][N:35]=4)=[CH:24][CH:23]=3)[C:8](=[O:20])[N:9]([CH2:12][CH2:13][N:14]3[CH2:15][CH2:16][O:17][CH2:18][CH2:19]3)[C:10](=[O:11])[C:5]=2[CH:4]=1)[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 136052290HCID 136052290, compound

Product 1

HCID 136348338HCID 136348338, compoundYield 60%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 8857Ethyl AcetateSolvent

Procedure

6-Ethyl-3-(2-morpholin-4-ylethyl)-1-{[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (0.26 g) was dissolved in ethyl acetate (8 mL) and acetone (2 mL), and 4N hydrochloric acid (ethyl acetate solution, 0.11 mL) was added. The precipitated solid was collected by filtration to give the title compound as colorless crystals (0.16. g, 60%).

Workup

  1. filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-c0ae2862cef24835a89586b5f3572afa
Source dataset
uspto-grants-2013_08
Patent number
US08501750B2

Reaction notes

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